呼吸道病原体和候选菌对牙膏基础材料的附着-试点研究
Anne Schmutzler1, Catalina Suzana Stingu2, Elena Günther3
1Department of Prosthetic Dentistry, Regensburg University Medical Center, 93042 Regensburg, Germany.
Journal of clinical medicine
|October 14, 2023
概括
牙膏材料会随着时间的推移积累呼吸道病原体和Candida物种. 在聚甲基甲酸 (PMMA) 和聚乙基 (PEEK) 材料之间没有发现微生物附着的显著差异.
科学领域:
- 口腔微生物学 口腔微生物学
- 生物材料科学 生物材料科学
- 牙修复 牙修复 牙修复 牙修复 牙修复
背景情况:
- 假牙是微生物殖民的储存库,可能会影响口腔健康.
- 了解与假牙基材的微生物相互作用对于预防感染至关重要.
研究的目的:
- 研究呼吸道病原体和Candida物种与不同假牙基材的附着.
- 为了比较热压聚甲基甲酸 (PMMA),CAD/CAM处理的PMMA和CAD/CAM处理的聚乙乙 (PEEK) 上的微生物积累.
主要方法:
- 制造了PMMA和PEEK的样本,并将它们放置在患者的假牙中24小时和4周.
- 使用质谱法 (MALDI-TOF) 培养并识别了附着微生物.
- 进行了定量微生物学分析和统计测试 (ANOVA).
主要成果:
- 总细菌数量从24小时显著增加到4周 (p ≤0.004).
- 在测试材料之间没有观察到微生物计数的显著差异.
- 呼吸道微生物始终被检测到; 坎迪达物种在四周后被确定.
结论:
- 牙膏基材支持呼吸道微生物和Candida物种的积累.
- 虽然材料类型没有显著影响微生物负载,但传统加工的PMMA显示出较高积累的趋势.
- 进一步的研究可能会探索减轻假牙表面微生物粘附的策略.
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