肝移植后患者的并发症
Carlotta Agostini1, Simone Buccianti1, Matteo Risaliti1
1Department of Experimental and Clinical Medicine, AOU Careggi, 50134 Florence, Italy.
Journal of clinical medicine
|October 14, 2023
概括
肝移植 (LT) 对肝衰竭和癌症至关重要,但器官短缺需要仔细选择接受者和扩大捐赠者标准. 像机器输液这样的进步正在改善边际捐赠者的结果,尽管长期并发症需要进一步研究.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植手术 移植手术
- 器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器
背景情况:
- 肝移植 (LT) 是肝衰竭和某些癌症的首要治疗方法.
- 增加的LT活动和扩大的适应症导致了严重的器官短缺.
- 解决器官稀缺问题需要优化接受者选择和扩大捐赠者池.
研究的目的:
- 审查目前关于肝移植短期和长期结果的文献.
- 突出最近在LT方面的发现和进展,特别是在边际捐助者方面.
- 在LT实践中确定挑战和达成共识的领域.
主要方法:
- 对已发表的病例系列和关于肝移植结果的研究进行了广泛的文献审查.
- 分析与边际供体利用和结果相关的数据.
- 检查机器 perfusion 技术的影响 (in situ 和 ex situ).
主要成果:
- 随着时间的推移,对LT的移植活动和指示得到了扩大.
- 使用边际捐赠者已经显示了逐渐改善的结果.
- 机器输液和更好的并发症管理可能有助于更好的结果.
- 长期并发症是越来越令人担忧的,因为患者的生存率增加.
结论:
- 跨中心的LT实践的异质性使得结果的比较变得复杂.
- 需要在专家之间达成更大的共识,以标准化和改进LT结果.
- 对优化捐赠者利用率和管理长期并发症的持续研究至关重要.
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