三甲糖-葡萄糖指数可能是预测慢性冠状动脉综合征中不良心血管结果的更好指标
Aslan Erdoğan1, Duygu İnan1, Ömer Genç1
1Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey.
Journal of clinical medicine
|October 14, 2023
概括
甘油三糖指数 (TyG) 是慢性冠状动脉综合征 (CCS) 患者主要心血管不良事件 (MACE) 的重要预测指标. 高TyG水平表明心血管事件和死亡率的风险更高.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 慢性冠状动脉综合征 (CCS) 构成显著的心血管风险.
- 替代标记物如甘油三糖指数 (TyG) 和血动脉动脉生成指数 (AIP) 被探索用于动脉样硬化评估.
- 在CCS患者中确定主要不良心血管事件 (MACE) 的可靠预测因素至关重要.
研究的目的:
- 研究慢性冠状动脉综合征 (CCS) 患者的甘油三指数 (TyG) 和主要不良心血管事件 (MACE) 之间的关联.
- 评估TyG和AIP作为动脉样硬化替代标记物的预测价值,以评估CCS患者心血管结果.
主要方法:
- 对715名中等风险CCS患者的回顾性分析.
- 卡普兰-梅尔图和考克斯的比例危险模型用于时间到事件分析.
- 多变量考克斯回归以确定MACEs的独立预测因子.
主要成果:
- 甘油三糖指数 (TyG) 被确定为MACEs的独立预测因子.
- 患有高TyG水平的患者表现出明显更高的MACE率 (18.7%对3.8%,p<0.001).
- 提升的TyG与脑血管事件,心力衰竭住院,心肌梗塞和死亡率的风险增加有关.
结论:
- 甘油三糖指数 (TyG) 可能成为慢性冠状动脉综合征 (CCS) 患者不良心血管结果的有价值的预测标志物.
- 在CCS患者心血管事件的风险分层中,TyG指数值得考虑.
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