沃格特-科亚纳吉-哈拉达疾病和COVID
Priscilla Manni1, Maria Carmela Saturno1, Massimo Accorinti1
1Ocular Immunovirology Service, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Journal of clinical medicine
|October 14, 2023
概括
沃格特-科亚纳吉-哈拉达病可以由COVID-19感染或接种疫苗引起. 早期的皮质类固醇治疗导致良好的视觉结果,即使在遗传倾向的个体.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 沃格特-科亚纳吉-哈拉达病 (VKH) 是一种罕见的多系统炎症疾病,影响眼,听觉,神经和全身系统.
- 新出现的证据表明,2019年新冠肺炎 (COVID-19) 感染和接种疫苗以及VKH疾病的发病或复发之间存在潜在联系.
研究的目的:
- 为提供VKH疾病的概述.
- 对与COVID-19感染和疫苗接种相关的VKH病例进行全面的文献审查.
- 讨论COVID-19后的VKH潜在的病原遗传机制和遗传倾向.
主要方法:
- 在COVID-19感染和接种疫苗后对VKH病例的文献综述.
- 对流行病学和临床发现的分析.
- 讨论病原遗传假设和遗传因素,包括HLA DR4.
主要成果:
- 与COVID-19前时代相比,VKH的流行病学或临床表现没有显著差异.
- 所有患者都对皮质类固醇治疗表现出迅速的反应,实现了良好的视觉预后.
- 在COVID-19疫苗接种后经常报告VKH疾病,突出显示其作为潜在触发者的作用.
结论:
- COVID-19 感染和接种疫苗可以引发 VKH 疾病,而 HLA DR4 可能会产生遗传倾向.
- 及时的皮质类固醇治疗确保了有利的视觉结果,支持持续的疫苗接种工作.
- 眼科医生必须保持警VKH发生或在COVID-19疫苗接种后复发,特别是在易受感染的个体中.
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