在分娩期间COMT基因多态,焦虑和疼痛感知之间的关系
Jadranka Šanjug1, Krunoslav Kuna2, Marina Šprem Goldštajn3
1Department of Gynaecology and Obstetrics, General Hospital Zabok and War Veterans' Hospital, Bračak 8, 49210 Zabok, Croatia.
Journal of clinical medicine
|October 14, 2023
概括
COMT基因多态性影响了分娩期间的疼痛感知. 具有GA基因型的女性报告疼痛较少,而AA基因型的女性显示焦虑较低. 氧化提供了抗焦虑作用,特别是在具有AA基因型的女性中.
科学领域:
- 遗传学 遗传学 是一个
- 产科 产科 产科 产科 产科
- 心理学 心理学 心理学
背景情况:
- 甲基转移酶 (COMT) 基因多态性与神经疾病,精神疾病和疼痛感知有关.
- 调查与分娩期间焦虑和疼痛有关的COMT基因变异对于了解个人对分娩和止痛的反应至关重要.
研究的目的:
- 检查COMT基因多态化与分娩妇女疼痛感知之间的关联.
- 评估COMT基因多态化对分娩期间焦虑水平的影响.
- 评估吸入氧化止痛药与COMT基因型有关的疗效.
主要方法:
- 181名经历了阴道分娩的妇女被分为有 (n=90) 和没有 (n=91) 吸入氧化止痛的组.
- 使用PCR从怀孕期间采集的血液样本确定了COMT基因多态性.
- 使用视觉模拟量表 (VAS) 自主评估疼痛感知,使用国家特征焦虑清单 (STAI-T) 测量焦虑.
主要成果:
- COMT基因型的流行:GG (22%),GA (53%) 和AA (25%).
- 与野生类型 (GG) 相比,在疼痛感知和GA (突变异位体) COMT基因型之间发现了负相关性,疼痛感知低0.46单位.
- AA基因型组的焦虑特征得分低于GA和GG组 (p > 0.042). 氧化在22%的中度疼痛女性中表现出止痛作用.
结论:
- COMT基因多态性显著影响分娩妇女的疼痛感知和焦虑.
- COMT基因的GA基因型与分娩期间减少疼痛感知有关.
- 氧化显示出抗焦虑疗效,特别是在具有AA基因型和轻度焦虑症的女性中.
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