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在预测儿科急性病的动力估计的淋巴细胞过率
Flavia Chisavu1,2,3, Mihai Gafencu1,2, Lazar Chisavu1,3
1University of Medicine and Pharmacy 'Victor Babes', 300041 Timisoara, Romania.
Journal of clinical medicine
|October 14, 2023
概括
球膜过率 (KeGFR) 的动力估计有效地预测了儿童急性损伤 (AKI) 的严重程度和结果. 这种方法有助于评估急性病 (AKD) 的进展和重大脏不良事件 (MAKE30).
科学领域:
- 儿科脏病学 儿科脏病学
- 功能评估 功能评估
- 急性损伤研究研究
背景情况:
- 建立了膜过率 (KeGFR) 的动力估计,用于预测儿科患者急性损伤 (AKI).
- 在预测AKI严重程度,急性病 (AKD) 的进展和30天后严重的脏不良事件 (MAKE30) 中,KeGFR的临床实用性需要进一步调查.
- 了解AKI患者的KeGFR动态对于改善患者管理和预测结果至关重要.
研究的目的:
- 评估KeGFR在预测已被诊断为AKI的儿科患者AKI严重程度和发展为AKD的临床实用性.
- 在这个队列中,检查30天 (MAKE30) 的重大脏不良事件中KeGFR的预测价值.
- 提出和验证一个新的KeGFR分期系统来预测AKI的严重程度和结果.
主要方法:
- 对803名儿童患者 (<18岁) 进行了回顾性分析,这些患者接受了AKI治疗.
- 在AKI的前24小时内计算KeGFR (KeGFR1) 和在AKD诊断前24小时内计算KeGFR (KeGFR2).
- 开发一种新的KeGFR分期系统 (1-5) 并评估其对AKD和MAKE30的预测价值,使用后勤回归和ROC分析.
主要成果:
- 较低的KeGFR值与增加的AKI严重程度有显著的相关性.
- KeGFR1和KeGFR2表现出对AKD发展的强有力的预测能力 (AUC 0.777-0.841,p < 0.001).
- KeGFR2显示了MAKE30的最高预测性能 (AUC 0.819),具有特定的敏感性和特异性;晚期的KeGFR阶段显著增加了AKD和MAKE30的风险.
结论:
- 基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基.
- 包括初始和AKD前测量的KeGFR动态,为AKD发展和MAKE30提供了重要的预测能力.
- 拟议的KeGFR分期系统为分层风险和指导儿科AKI临床管理提供了一种实际方法.
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