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延迟移植功能的脏存活影响取决于脏捐赠者风险指数:单中心队列研究
Joseba Salguero1, Laura Chamorro2, Enrique Gómez-Gómez2
1Urology Department, Infanta Margarita Hospital, 14940 Cabra, Spain.
Journal of clinical medicine
|October 14, 2023
概括
延迟移植功能 (DGF) 显著增加了移植移植的移植损失,特别是在高风险的捐赠者 (KDRI ≥1) 身上. 低风险捐赠者 (KDRI < 1) 与DGF没有显著差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 器官移植 器官移植 器官移植
背景情况:
- 延迟移植功能 (DGF) 是移植的常见并发症,特别是来自已故捐赠者的移植.
- 关于DGF对植入物存活的长期影响进行了辩论,报道了相互矛盾的结果.
- 移植弹性和再生能力可能会影响DGF的结果.
研究的目的:
- 调查DGF对移植存活率的影响.
- 根据捐赠者风险区分结果,特别是脏捐赠者风险指数 (KDRI) < 1 和KDRI ≥ 1.
主要方法:
- 从2015年1月到2019年12月进行移植的回顾性队列研究.
- 排除同时进行多器官移植,初级非功能移植和手术并发症.
- 使用单变量,多变量和倾向得分匹配 (PSM) 方法进行分析.
主要成果:
- 在322个已故的捐赠脏中,83个经历了DGF.
- 具有KDRI ≥ 1和DGF的移植显示了显著更高的移植损失风险 (HR:4.17).
- 对于KDRI<1的移植,在DGF组和非DGF组之间没有观察到移植存活率的显著差异.
结论:
- 在移植中,DGF是移植损失的重要危险因素.
- DGF的负面影响在来自高风险捐赠者的移植中尤为明显 (KDRI ≥1).
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