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作为一个潜在的附加生物标志物来改善IMDC中间预测得分的PNI

İbrahim Vedat Bayoğlu¹, Javid Hüseynov¹, Alper Topal²

¹Department of Medical Oncology, School of Medicine, Marmara University, 34899 Istanbul, Turkey.

Journal of clinical medicine

|October 14, 2023

概括

调整后的PNI-IMDC风险评分有助于分层介质转移性细胞癌 (mRCC) 患者接受一线TKIs. 预治疗PNI可以进一步完善预后模型,以改善患者分层.

科学领域:

在瘤学瘤学.
生物标志物生物标志物
临床试验临床试验

背景情况:

接受一线氨酸激酶抑制剂 (TKI) 的转移性细胞癌 (mRCC) 患者通常属于中等风险组.
准确的风险分层对于优化mRCC治疗策略至关重要.

研究的目的:

为了评估调整后的预后营养指数 (PNI) -国际转移性数据库协作 (IMDC) 风险评分系统.
评估其在分层中等风险mRCC患者治疗一线TKIs中的作用.
探索PNI作为一种附加生物标志物,用于改进预后建模.

主要方法:

对185名用一线TKIs治疗的mRCC患者的分析.
使用调整后的PNI-IMDC模型对中间组进行分层,分为PNI高和PNI低的子组.
卡普兰-梅尔和考克斯回归分析用于统计评估.

主要成果:

调整后的PNI-IMDC得分显示出与经典的IMDC和PNI相似的预后值.
调整后的PNI-IMDC系统允许在中等风险组内进行更均的差异化.
总生存期 (OS) 的独立预测因素包括切除术,调整的有利/中间 (PNI-高) 状态,ECOG性能得分和骨转移.

结论:

预处理PNI为调整后的PNI-IMDC模型提供了有价值的附加生物标志物.
这种综合方法可以增强在一线TKIs上的中等风险mRCC患者的预后建模.
建议进行进一步的验证研究来证实这些发现.

关键词:

在IMDC模型中,IMDC模型是:在 PNI PNI 中.调整后的PNI-IMDC模型.转移性RCC是什么意思预后预后预后

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