三个澳大利亚社区暴露在Per-和多基基物质中的不良周产期结果的相对风险:数据链接研究
Hsei Di Law1, Deborah A Randall2, Bruce K Armstrong3
1National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT 2601, Australia.
International journal of environmental research and public health
|October 14, 2023
概括
消防泡中的和多基物质 (PFAS) 可能会增加孕妇死产和高血压疾病的风险. 虽然在受污染的澳大利亚地区观察到一些高风险,但研究结果在所有地点都不一致.
科学领域:
- 环境健康 环境健康
- 围产期流行病学 围产期流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 含有per-和多基物质 (PFAS) 的消防泡导致澳大利亚住宅区的环境污染.
- 对于居住在这些暴露于PFAS的地区的母亲的潜在不良产周结果存在担忧.
研究的目的:
- 为了调查生活在澳大利亚PFAS污染地区的母亲是否比生活在未暴露地区的母亲有更高的不良周产期结果风险.
主要方法:
- 从受PFAS污染的地点 (Katherine,Oakey,Williamtown) 的住宅数据与司法管辖区的围产期数据收集联系起来.
- 来自居住在暴露和比较区域的母亲的精选怀孕,检查了12个二元周产期结果和3个生长测量.
- 估计调整后的相对风险 (RRs) 和资金差异,控制社会人口统计学因素和混因素.
主要成果:
- 分析包括了16970例 (NT),4654例 (Qld) 和7475例 (NSW) 的怀孕.
- 在Oakey的死产 (RR=2.59) 和在Williamtown的产后出血 (RR=1.94) 和妊娠引起的高血压 (RR=1.88) 中观察到高风险.
- 其他结果显示没有显著差异或由于事件数量较少而不确定.
结论:
- 有限的证据表明,在消防泡污染PFAS的地区,围产期不良结果的风险增加.
- 在特定领域观察到的较高风险不一致,可能归因于机会,偏见或混因素.
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