分析母婴肥胖的乳酪中的活性化合物:一个网络药理学和分子对接研究
Ruth Naomi1, Soo Huat Teoh2, Hashim Embong3
1Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Foods (Basel, Switzerland)
|October 14, 2023
概括
乳酸奶中的elateriospermum tapos (E. tapos) 化合物显示出对抗孕产妇肥胖的潜力. 网络药理学确定了关键的目标和途径,建议产后体重管理的治疗应用.
科学领域:
- 药理学和营养保健品药理学和营养保健品
- 计算生物学 计算生物学
- 孕产妇健康 孕产妇健康
背景情况:
- 怀孕期间母亲的肥胖对后代的健康构成风险.
- 乳腺精子后的酸奶 (E. tapos) 正在研究其在管理产后体重保持方面的潜力.
研究的目的:
- 通过网络药理学研究E. tapos酸奶中的生物活性化合物的药理机制,以对抗孕产妇肥胖.
主要方法:
- 从E. tapos酸奶中确定了生物活性化合物,并预测了它们的基因标.
- 从公共数据库中收集了与母亲肥胖相关的基因.
- 使用了网络药理学,包括蛋白质与蛋白质相互作用,基因本体学和KEGG通路分析. 分子对接验证了化合物-标相互作用.
主要成果:
- 从E. tapos酸奶中确定了三种生物活性化合物,针对380个基因,其中240个与孕产妇肥胖症有关.
- 这些化合物表现出与关键标具有有利的结合亲缘关系.
- 确定了涉及蛋白质酸化,炎症和脂质代谢的途径.
结论:
- 在E. tapos酸奶中的生物活性化合物具有针对孕产妇肥胖的潜在药理作用.
- 这些发现支持进一步研究E. tapos酸奶作为治疗策略,用于管理孕产妇肥胖和产后体重.
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