在硬口腔/上膜癌症中对大骨侵袭的预测:多中心回顾性研究
Nayeon Choi1, Jeon Yeob Jang2, Min-Ji Kim3
1Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea.
Cancers
|October 14, 2023
概括
在硬口腔/上膜癌症中,可以使用成像和临床数据预测骨入侵. 包括CT,瘤大小和患者因素在内的综合模型,随着可选的PET/CT SUVmax,可以提高预测准确度.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 头部和部手术 头部和部手术
背景情况:
- 大骨侵袭 (MBI) 是一个已知的并发症在硬口腔/上膜 (HP/UA) 癌症.
- 关于在HP/UA癌症患者中预测MBI的研究有限.
研究的目的:
- 开发和评估HP/UA癌症中MBI的预测模型.
- 确定MBI预测的关键临床和放射性因素.
主要方法:
- 这是一项多中心对144例HP/UA癌症病例的回顾性研究.
- 由外科病理学或放射学定义的MBI.
- 使用CT和PET/CT的临床和放射学变量开发的预测模型.
主要成果:
- 仅CT就预测了MBI,其AUC为0.779.
- 结合CT,瘤尺寸和临床因素 (性别,结节转移) 的模型改善了AUC至0.854.
- 包括PET/CTSUVmax进一步增强了预测能力 (AUC=0.911).
- 一个评分系统将患者分为低,中,高MBI风险组.
结论:
- 在HP/UA癌症中预测MBI是可行的,具有很高的歧视性.
- 结合CT发现,瘤尺寸,临床因素和PET/CT SUVmax,提供了一个强大的预测策略.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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