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上腺附带瘤和其他内分泌相关的腺瘤:皮质醇分泌有多重要?
Aura D Herrera-Martínez1,2, Ángel Rebollo Román1,2, Eider Pascual Corrales3,4
1Endocrinology & Nutrition Department, Hospital Reina Sofia, 14004 Córdoba, Spain.
Cancers
|October 14, 2023
概括
在上腺意外瘤 (AI) 中,轻度自主皮质醇分泌 (MACS) 不会增加其他腺瘤,但会引起代谢问题. 患有MACS和甲状腺或其他腺瘤的患者面临更高的死亡风险.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 内部医学 内部医学
背景情况:
- 上腺意外瘤 (AI) 是常见的临床发现,其中40%与高皮质醇症有关.
- 已知轻度自主皮质醇分泌 (MACS) 影响疾病结果,但其对良性瘤的影响尚不清楚.
- 了解MACS与其他腺瘤之间的关系对于患者管理至关重要.
研究的目的:
- 为了比较不同位置 (甲状腺,副甲状腺,垂体等) 腺瘤的患病率. 在患有非功能性上腺瘤 (NFAI) 和MACS的患者中.
- 调查MACS与其他良性瘤的发展之间的关联.
主要方法:
- 这是一项多中心的回顾性研究,涉及923名上腺偶发性瘤患者.
- 患者被分为NFAI和MACS组.
- 分析了腺瘤在其他内分泌部位和代谢并发症的患病率.
主要成果:
- 在MACS和NFAI组之间,脑垂体,甲状腺,副甲状腺或其他内分泌相关腺瘤的患病率没有显著差异.
- 在所有患者中,除上腺外的腺瘤在36%的患者中被发现,两组的发病率相似 (33%对32%).
- 患有MACS的患者表现出较高的代谢并发症和死亡率,特别是那些同时存在甲状腺或其他内分泌相关腺瘤的患者.
结论:
- 上腺附带瘤经常与其他内分泌部位的腺瘤有关.
- 轻度自主皮质醇分泌不会影响其他内分泌腺瘤的发生.
- MACS与较高的代谢并发症和死亡率有关,特别是当其他腺瘤存在时.
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