儿科肝细胞腺瘤:什么是已知的,什么是新的?
Andres F Espinoza1, Sanjeev A Vasudevan1, Prakash M Masand2
1Divisions of Pediatric Surgery and Surgical Research, Michael E. DeBakey Department of Surgery, Pediatric Surgical Oncology Laboratory, Texas Children's Surgical Oncology Program, Texas Children's Liver Tumor Program, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Cancers
|October 14, 2023
概括
儿科肝细胞腺瘤 (HCAs) 与成人形式不同,通常与综合征有关. 这些罕见的肝脏瘤的管理考虑瘤大小,突变和患者因素.
科学领域:
- 儿科肝病学 儿科肝病学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 目前对儿科肝细胞腺瘤 (HCAs) 的分类主要依赖于成人数据.
- 儿科HCA很少见,通常与综合征或肝脏异常背景有关,导致分类挑战.
- 虽然通常是良性的,但一些儿科HCA表现出不典型的特征或β-catenin突变,构成恶性转变的风险.
研究的目的:
- 审查有关儿科肝细胞腺瘤 (HCAs) 的当前数据.
- 突出了儿科HCA的诊断和管理策略.
- 根据成人标准对儿科HCA进行分类所面临的挑战.
主要方法:
- 小儿肝细胞腺瘤的文献综述.
- 对诊断标准和分类系统的分析.
- 基于临床和病理特征的管理方法的总结.
主要成果:
- 与成人形式相比,儿科HCAs具有独特的特征.
- 几种儿科病变仍然是"不可分类"使用基于成人的系统.
- 管理策略是根据病变大小,患者人口统计和分子特征量身定制的.
结论:
- 儿科HCAs需要不同的诊断和管理方法.
- 需要进一步的研究来完善儿科HCA的分类和治疗方案.
- 多学科管理对于优化HCA儿童的治疗结果至关重要.
相关概念视频
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...
Insulin and C-peptide are co-secreted in...
Cells and Secretions of the Pancreas
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...


