肥胖相关的特征是否通过血清丸激素影响前列腺癌风险? 一个门德尔的随机化研究
Chi Yuan1,2, Zhongyu Jian2,3, Shijian Feng2
1Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Cancers
|October 14, 2023
概括
较高的体重指数 (BMI) 与较低的生物可用 (BT) 和降低前列腺癌 (PCa) 风险有关. BT调解了这种效应,表明肥胖如何影响PCa风险的机制.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 肥胖与包括癌症在内的各种健康结果有关.
- 肥胖,和前列腺癌 (PCa) 风险之间的关系是复杂的,需要进一步调查.
- 门德尔随机化 (MR) 为探索暴露与疾病之间的因果关系提供了一个强大的工具.
研究的目的:
- 调查的调解或混作用,肥胖相关的特征和前列腺癌 (PCa) 风险之间的关联.
- 利用孟德尔的随机化 (MR) 分析来阐明因果途径.
主要方法:
- 利用来自欧洲祖先的大量遗传数据来研究肥胖特征 (BMI,WHR,WHRadjBMI).
- 从英国生物银行参与者中提取了与相关的数据 (生物可用[BT],总[TT],性激素结合型全球蛋白[SHBG]).
- 使用了来自PRACTICAL联盟的PCa病例和对照的总结级数据进行MR分析.
主要成果:
- 在较高的BMI和降低的PCa风险 (OR=0.91) 之间发现了因果关系.
- 增加的BT水平与PCa风险增加有关 (OR=1.15).
- 较高的BMI因果降低了BT水平 (beta=-0.27),这表明BT调解了BMI-PCa关系. 多变量MR通过BT证实BMI对PCa风险的间接影响 (OR=0.96).
结论:
- 提供了遗传证据,表明血清BT调解BMI对PCa风险的影响.
- 通过对丸激素水平的影响,确定了肥胖可能降低前列腺癌风险的潜在机制.
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