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在临床前动物实验研究中报告3R方法 - 一项全国性的研究

Birgitte S Kousholt¹, Kirstine F Præstegaard¹, Jennifer C Stone^2,3

¹Department of Clinical Medicine, AUGUST, Aarhus University, 8200 Aarhus, Denmark.

Animals : an open access journal from MDPI

|October 14, 2023

概括

在临床前动物研究中,对3R (替代,减少,改进) 的报告是不够的. 虽然在2009年至2018年期间,一些报告略有增加,但方法细节基本上缺失,阻碍了科学进步.

科学领域:

动物研究伦理动物研究伦理
临床前研究报告标准
科学出版的最佳实践

背景情况:

3R (替代,减少,改进) 是动物实验的伦理原则.
研究人员普遍认为3Rs的建议是积极的.
在出版物中传播3Rs方法可以加速采用.

研究的目的:

评估丹麦机构在同行评审的临床前动物研究中报告3Rs原则的情况.
评估2009年至2018年期间3R报告的趋势.

主要方法:

系统搜索和500个临床前动物研究的随机抽样.
分析了2009年至2018年间发表的与丹麦大学相关的作者合作的研究.
关键词搜索和句子分析用于3Rs术语和方法报告.

主要成果:

总体而言,3Rs报告率很低,随着时间的推移,改善程度有限.
报告"3Rs"关键词的数量从0%增加到3.2%.
报告"减少"和"精炼"增加,但没有报告"替代". 方法上的细节很少.

结论:

目前在临床前出版物中对3R方法的报道不足.
改善报告是必要的,以有效指导研究人员.
需要教育和资金等额外的战略来推进3R的实施.

关键词:

3Rss是什么意思时间到达了.动物福利动物福利临床前动物研究.减少减少减少减少精炼 refinement 精炼 refinement 精炼 refinement 精炼 refinement 精炼 refinement 精炼 refinement 精炼 refinement 精炼 refinement 精炼 refinement 精炼替代品替代品替代品替代品报告报告报告报告报告报告报告

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