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梅瓦科尔/聚乙/二乙基甲酸) 作为固体溶液:制备,提高溶解度和药物输送

Mohammed Alassaf¹, Saad Mohammed Alqahtani¹, Rana Salem Al Khulaifi¹

¹Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

|October 14, 2023

概括

新的Mevacor (MVR) 药物载体系统,MVR/Poly (乙酸-co-2-基乙基甲酸) (VAC-HEMA),提供更好的溶解性和受控释放. 优化的MVR/VAC-HEMA配方显示出短期和长期胃肠道过境的前景.

科学领域:

聚合物科学聚合物科学
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

开发有效的药物输送系统对于改善治疗结果至关重要.
聚合物药物载体提供可调节的特性,用于控制药物释放.
梅瓦科尔 (MVR) 需要优化的输送策略来提高其溶解性和生物可用性.

研究的目的:

为了合成和描述Mevacor (MVR) 装载的聚乙酸-co-2-乙烯基甲基酸 (VAC-HEMA) 共聚合物药载体.
研究MVR含量和pH对MVR/VAC-HEMA系统的胀和药物释放特性的影响.
评估药物载体系统在不同胃肠道传输时间的体外性能.

主要方法:

乙乙烯酸和2-基乙基甲酸盐的自由基共聚合与Mevacor.
使用FTIR,1H NMR,DSC,SEM和XRD进行表征.
在不同的pH值下进行体外胀能力和药物释放研究.

主要成果:

梅瓦科尔颗粒均分散在共聚合物矩阵中,形成固体溶液.
MVR/VAC-HEMA系统在MVR负载水平为0.25-2.00 wt%时没有显示显著的细胞毒性.
与免费药物相比,MVR的溶解性显著增加 (22-37倍),释放概况优化为短 (0.5 wt% MVR) 和长 (2.0 wt% MVR) 的胃肠道过渡.

结论:

MVR/VAC-HEMA系统是一个有前途的,无毒的药物载体,具有增强的MVR溶解性和受控释放能力.
药物载体系统可以通过调整MVR内容来适应特定的胃肠道运输时间.
这种新型药物输送系统有可能提高Mevacor治疗效率.

关键词:

一个LED灯的灯光 LED灯光.梅瓦科尔 (Mevacor) 的交付方式梅瓦科尔/聚乙烯乙-co-2-基甲基甲酸盐)通过光聚合聚合聚合.一个固体溶液固体溶液.可溶性增强提高可溶性

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