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用不同程度的结构顺序与或丰富的生物活性玻璃作为基托桑基复合脚手架的组件,用于骨组织工程

Lidia Ciołek¹, Małgorzata Krok-Borkowicz², Arkadiusz Gąsiński³

¹Biomaterials Research Group, Łukasiewicz Research Network-Institute of Ceramic and Building Materials, 31-983 Kraków, Poland.

|October 14, 2023

概括

这项研究探讨了基于酸盐的新型支架,包括用 (SrO) 或 (ZnO) 修改的生物活性玻璃 (BG) 用于骨再生. 结果显示可调节的离子释放和细胞相容性,为增强骨组织工程提供了潜力.

科学领域:

生物材料科学生物材料科学
材料化学材料化学
生物技术是生物技术.

背景情况:

创新的生物材料对于骨组织的整合和再生至关重要.
基于酸盐的支架为骨缺陷修复提供了一个有希望的平台.
生物活性眼镜 (BGs) 可以通过离子释放和酸盐形成来增强骨愈合.

研究的目的:

为了评估SiO2-P2O5-CaO生物活性玻璃的实用性,在基托基架中富含SrO或ZnO.
研究BG修饰和热处理对脚手架性能和生物性能的影响.
评估离子释放概况和与骨质母细胞类细胞的细胞相容性.

主要方法:

用sol-gel方法进行BG合成,然后进行热处理.
化素/BG复合材料的脚手架制造.
使用TG-DTA,FTIR和SEM-EDS进行表征.
在体外评估包括模拟体液 (SBF) 测试,离子释放分析和MG63细胞培养.

主要成果:

用SrO或ZnO对BG进行修改,显著降低了晶相含量.
复合材料在SBF中显示出生物活性,释放Ca2+,Zn2+和/或Sr2+离子.
非修改的BG复合物显示出最高的细胞相容性,其次是SRO修改的.
用ZnO修饰的BG复合物表现出剂量依赖的细胞相容性,在特定的离子释放水平下具有可接受的结果.

结论:

通过调整BG成分和热处理,可定制基托/BG复合物的生物性能.
加入SrO和ZnO可以调节用于骨组织工程应用的离子释放和细胞兼容性.
优化的BG修饰为开发先进的骨再生材料提供了一条途径.

关键词:

可生物降解的复合材料生物玻璃是一种生物玻璃.基多酸盐的使用方法玻璃的内部结构是玻璃.

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