合成与氨酸相关的L-氨酸和L-氨酸相关的PLGA作为生物降解的聚合物
1Department of Analytical Chemistry, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Yalnızbağ, Erzincan 24002, Türkiye.
Polymers
|October 14, 2023
概括
新的生物降解聚合物是通过将聚乳-co-glycolic acid (PLGA) 与氨基酸L-ornithine和L-glutamine结合而创建的. 这些新的PLGA衍生品表现出增强的特性,使它们成为生物材料应用的前景.
科学领域:
- 聚合物化学 聚合物化学
- 生物材料科学 生物材料科学
- 有机合成 有机合成
背景情况:
- 聚乳-同-甘油酸 (PLGA) 是一种广泛使用的可生物降解聚合物.
- L-ornithine和L-glutamine是生物学上重要的氨基酸,参与运输.
- 开发具有增强性能的新型PLGA衍生品对于先进的生物材料应用至关重要.
研究的目的:
- 通过将PLGA与L-ornithine和L-glutamine结合,合成新的可生物降解PLGA衍生物.
- 研究合成的PLGA-氨基酸结合物的化学,热和降解性质-结构关系.
- 评估这些新衍生品作为生物材料原料的潜力.
主要方法:
- 通过聚凝和环开聚合物合成PLGA的合成.
- 使用EDC合反应将L-ornithine或L-glutamine结合到PLGA.
- 使用13C NMR和FTIR光谱学进行化学结构的表征.
- 评估热稳定性和降解性质.
主要成果:
- 通过光谱分析 (NMR,FTIR) 证实了PLGA-L-ornithine和PLGA-L-glutamine衍生物的成功合成.
- 新的衍生品表现出良好的热稳定性,并被归类为能量材料.
- 由于增强的水友性和表面侵蚀,PLGA-L-ornithine和PLGA-L-glutamine与原始PLGA相比呈现出更快的降解率.
结论:
- 可以成功地将L-ornithine和L-glutamine与PLGA结合起来,以创建新的可生物降解聚合物.
- 这些PLGA-氨基酸衍生物具有有利的热和降解特性.
- 开发的与L-ornithine和L-glutamine相关的PLGA是开发先进生物降解生物材料的有希望的候选者.
关键词:
在EDC合器中使用EDC合器.L-谷氨胺是一种L-Glutamine.对于L-ornithine来说,这是一个很好的方法.在 ROP ROP ROP 中使用.氨基酸氨基酸是一种氨基酸.生物类似药的生物类似药.在体外降解降解聚乳-同-甘油酸) 的使用.聚聚是什么意思 聚聚更多相关视频
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