迁移研究和内分泌干扰活动:化品塑料包装的化学安全性
Elias Bou-Maroun1, Laurence Dahbi2, Laurence Dujourdy3
1PAM UMR A 02.102, Food and Microbiological Processes, Institut Agro, Université Bourgogne Franche-Comté, 1 Esplanade Erasme, F-21000 Dijon, France.
Polymers
|October 14, 2023
概括
塑料包装可以将内分泌干扰化学物质 (EDC) 浸出到化品模拟剂中. 油有效提取了抗雄激素化合物,而甘油则表现出雌激素活性,这凸显了模拟剂选择在安全性评估中的重要性.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 塑料包装广泛用于化品.
- 内分泌干扰化学物质 (EDC) 从包装进入产品的潜在迁移是一个安全问题.
- 了解化学特征和内分泌活性对于风险评估至关重要.
研究的目的:
- 研究塑料包装材料的内分泌活性和化学特征.
- 评估EDCs迁移到各种化品模拟剂中的情况.
- 评估不同模拟剂在安全测试中的相关性.
主要方法:
- 实验室基于细胞的记者基因测定用于确定内分泌活性.
- 气色谱与质谱学 (GC-MS) 结合,分析了化学资料.
- 迁移分析模拟了使用六种不同的仿真剂和各种塑料类型的化品接触.
主要成果:
- 在水性模拟剂浸出物中没有检测到内分泌活动.
- 油提取出最多的抗雄激素化学物质,而糖则表现出雌激素活性.
- 两个主要的EDCs,2,4-di-tert-butylphenol和7,9-di-tert-butyl-1-oxaspiro[4,5]deca-6,9-diene-2,8-dione,在大多数聚合物中发现,特别是在中.
结论:
- 甘油和液态抛是评估释放化合物的内分泌活性的相关和互补的模拟剂.
- 该研究强调了为精确评估塑料包装的安全性而选择适当的模拟剂的重要性.
- 结合生物测试和分析化学的综合方法对于评估包装材料中的潜在内分泌干扰剂是有效的.
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