L.Crocus sativus 提取物 (番石榴) 有效降低单一治疗中的关节炎和炎症参数,并在辅助性关节炎中与甲索特酸结合使用
Martin Chrastina1,2, František Dráfi1, Katarína Pružinská1,2
1Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine SAS, 841 04 Bratislava, Slovakia.
Nutrients
|October 14, 2023
概括
沙夫兰提取物 (SF) 在类风湿性关节炎模型中显示出抗炎和抗关节炎的潜力. 结合SF与甲状腺酸盐 (MTX) 的治疗效果比单独治疗更强.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 类风湿性关节炎 (RA) 是一种影响多个器官的自身免疫性炎症性疾病.
- 甲托雷克萨特 (MTX) 是一种标准的RA疗法,但其安全性受到限制.
- 克罗库斯·萨蒂斯L. (番茄) 提取物 (SF) 具有已知的抗炎性质.
研究的目的:
- 在辅助性关节炎的小鼠模型中研究SF单一治疗及其与MTX的组合的治疗潜力.
- 评估SF和MTX对生物识别,免疫学,生物化学和基因表达参数的影响.
主要方法:
- 在老鼠中诱导的辅助性关节炎.
- 治疗组包括SF单疗法 (两剂),MTX单疗法和SF与MTX的组合.
- 评估参数:体重,关节炎得分 (AS),后腿体积 (CHPV),肝脏mRNA表达,以及血/关节/脏的生物化学和免疫标记 (GGT,IL-17A,IL-1β,MMP-9,CRP,CD36).
主要成果:
- SF单疗显示了部分抗关节炎作用,SF2 (50 mg/kg) 显著改善了CHPV和免疫学参数 (IL-17A,IL-1β,MMP-9).
- 与SF和MTX的联合治疗显著改善了所有生物识别参数,并减少了AS和CHPV,与MTX单独治疗相比.
- SF单疗和组合疗法降低了肝脏IL-1βmRNA表达;SF1也降低了肝脏CD36mRNA表达.
结论:
- 沙法兰提取物 (SF) 在单一治疗中表现出部分抗关节炎和抗炎作用.
- 将SF与甲状腺素 (MTX) 结合起来,显著提高了辅助性关节炎的治疗结果.
- 作为类风湿性关节炎的辅助疗法,SF显示出前景,可能减轻MTX限制.
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