阿罗尼亚在2型糖尿病治疗方案中的作用
Christine B Christiansen1, Per B Jeppesen1, Kjeld Hermansen1,2
1Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.
Nutrients
|October 14, 2023
概括
发酵的阿罗尼亚提取物在2型糖尿病 (T2DM) 患者的葡萄糖依赖胰岛素 (GIP) 中略有增加. 然而,在这项研究中,发酵或非发酵的阿罗尼亚都没有显著影响血糖控制或其他标记物.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿罗尼亚梅拉诺卡帕果是强大的抗氧化剂,对2型糖尿病 (T2DM) 有潜在的益处.
- 阿罗尼亚化合物的低生物可用性可能会限制它们的治疗疗效.
- 发酵是作为一种提高阿罗尼亚生物可用性和潜在健康影响的方法来探索的.
研究的目的:
- 调查发酵的阿罗尼亚提取物 (FAE),非发酵的阿罗尼亚提取物 (AE) 和安慰剂对T2DM患者的血糖控制和相关生物标志物的比较作用.
- 评估发酵是否改善了阿罗尼亚补充剂的代谢益处.
主要方法:
- 采用了三盲,三交叉研究设计,有23名参与者完成了试验.
- 干预期持续了八周,涉及每天食用含有FAE,AE或安慰剂的零食吧.
- 关键的结果包括血红蛋白A1c,果糖胺,胰岛素,葡萄糖,内激素 (GLP-1,GIP),葡萄糖和口服葡萄糖耐受性测试.
主要成果:
- 与安慰剂相比,FAE的补充导致了依赖葡萄糖的胰岛素 (GIP) 水平在统计学上显著增加.
- 在FAE,AE和安慰剂组之间没有观察到血红蛋白A1c,果糖胺,胰岛素,葡萄糖,GLP-1或葡萄糖的显著差异.
- 该研究发现,阿罗尼亚提取物对T2DM患者的血糖控制没有总体临床影响.
结论:
- 虽然FAE补充剂增加了GIP,这表明代谢影响的潜在途径,但它并没有转化为T2DM队列中血糖控制标志物的显著改善.
- 在这项研究中,通过发酵提高生物可用性并没有与非发酵的阿罗尼亚或安慰剂相比产生更好的临床结果.
- 需要进一步的研究来阐明发酵增强的阿罗尼亚在治疗2型糖尿病中的确切作用和临床意义.
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