维生素D与儿童神经发育 - - 一个后期分析
Megan D Rodgers1, Molly J Mead1, Caroline A McWhorter1
1College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Nutrients
|October 14, 2023
概括
儿童维生素D水平较高与神经发育结果更好有关. 孕妇在怀孕期间补充维生素D可能会对孩子的认知和语言发育产生积极影响.
科学领域:
- 儿科健康 儿科健康
- 神经科学是一个神经科学.
- 营养科学 营养科学
背景情况:
- 维生素D (VitD) 在神经发育中起作用,但它的确切影响仍在争论中.
- 较高的25-基维生素D (25(OH) D) 水平通常与改善的神经发育结果有关.
- 相互矛盾的数据需要进一步研究维生素D状态与儿童神经发育之间的关系.
研究的目的:
- 为了检查母亲维生素D补充剂剂量与3-5岁儿童后代神经发育结果之间的关联.
- 为了研究循环中的25...OH) D度与神经发育表现之间的关系.
- 探索维生素D结合蛋白 (VDBP) 基因型对神经发育轨迹的影响.
主要方法:
- 怀孕妇女被随机分配,每天接受400,2000或4000 IU维生素D3.
- 后代在3-5岁时使用Brigance屏幕进行了神经发育评估.
- 测量包括出生时和3-5岁时的25...OH) D度,以及VDBP基因定型.
主要成果:
- 在评估时增加的25~OH) D水平与更好的整体神经发育得分相关 (强度系数).
- 接受每天2000 IU的母亲的孩子与标准剂量组相比,语言成绩有所改善.
- 特定的VDBP基因型 (Gc1f-1s,Gc1f-2) 与更高的学业成绩和较低的语言成绩有关.
结论:
- 较高的早期25~OH) D度和怀孕期间母亲增加的维生素D摄入量可能会对神经发育产生积极影响.
- VDBP基因型似乎是神经发育的一个重要因素,明显地影响着不同的发育领域.
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