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调节食欲的荷尔蒙的变化,女孩中部早期或早期的青春期

Galateia Stathori¹, Anastasia-Maria Tzounakou¹, George Mastorakos²

¹Center for the Prevention and Management of Overweight and Obesity, Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.

|October 14, 2023

概括

女孩中部早期青春期 (CPP) 与肥胖和饮食有关,可能会改变食欲激素. 这项研究检查了CPP女孩的这些荷尔蒙变化,发现升高的勒和改变的 ghrelin 水平.

科学领域:

儿科内分泌学儿科内分泌学
神经内分泌学神经内分泌学
代谢障碍代谢障碍代谢障碍

背景情况:

中部早期青春期 (CPP) 患病率在全球范围内不断上升,特别是在女孩中,与儿童肥胖和饮食因素有关.
肥胖和某些饮食可能会改变调节食欲的荷尔蒙,这些荷尔蒙在下丘脑内在释放性腺激素 (GnRH) 神经元附近起作用.
这种近距离表明,食欲激素失调与CPP的出现之间存在潜在的联系.

研究的目的:

调查诊断为中部早熟青春期 (CPP) 的女孩食欲调节激素的变化.
探索饮食诱导的下丘脑炎症在CPP病理生理学中的潜在作用.

主要方法:

对CPP女孩食欲调节激素度的现有证据的审查.
对检查激素特征的研究进行分析,包括勒素,格林素,内斯法廷-1,奥雷辛-A和胰岛素.

主要成果:

在CPP的女孩中观察到较高的丁度.
在CPP的女孩中发现了较低的格林度.
在早发痛的女孩中,观察到纳斯法廷-1和奥雷辛-A度的增加.
在初潮早期的女孩中,胰岛素度升高.

结论:

患有CPP的女孩在调节食欲的关键激素中表现出显著的变化,包括勒素,格林素,内斯法丁-1,欧素-A和胰岛素.
这些荷尔蒙变化可能受到肥胖和饮食模式的影响,这有助于CPP的发展.
对下丘脑炎症和激素通路的进一步研究是有必要的,以了解CPP的病理生理学.

关键词:

这就是GLP-1.纳斯法-1是一种尼斯法-1.素-A是一种素.中央早期青春期早期青春期儿童的肥胖症儿童的肥胖症格林激素是什么格林激素是什么勒普丁是一种素.

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