协调复合体是从具有抗菌和抗真菌性能的迪托普特醇-皮拉醇联体构建的
Youssef Draoui1, Smaail Radi1, Mohamed El Massaoudi1
1LCAE, Department of Chemistry, Faculty of Science, University Mohamed I, P.O. Box 524, Oujda 60 000, Morocco.
Molecules (Basel, Switzerland)
|October 14, 2023
概括
包含1,2,4-二醇连接体的新型金属复合物显示出有前途的抗菌和抗真菌活性. 这些化合物,包括,,和铜复合物,显示出抗菌应用的潜力.
科学领域:
- 协调化学 协调化学
- 超分子化学 超分子化学
- 药用化学 医学化学
背景情况:
- 新型1,2,4-triazole连接物的合成:3-(3,5-二甲基-1H-pyrazol-1-yl) - 1H-1,2,4-triazole (L).
- 四种单核金属复合物的制备:[NiL3](ClO4) 3 (1),[CoL3](ClO4) 2·2H2O (2),[CdL2Cl2] (3) 和[CuL3](NO3) 2 (4).
研究的目的:
- 研究合成的金属复合物的结构特征.
- 分析结和对抗离子对超分子组合的影响.
- 评估复合物和连接物的生物活性,特别是抗菌和抗真菌特性.
主要方法:
- 单晶X射线衍射用于结构确定复合物1-4.
- 配体和复合物的光谱表征.
- 在体外抗菌试验对抗阳性和阴性细菌.
- 在体外抗真菌测定对Fusarium oxysporum f. sp. 这是阿尔贝迪尼斯人.
主要成果:
- 确定了1-4个复合体的结构,揭示了不同的晶体空间组 (P63/m,P-1,P1,P21/c).
- 超分子结构受到键网络和对抗离子的影响.
- 所有合成的复合物都表现出对测试的细菌菌株具有有利的抗菌活性.
- 复合物3 (Cd) 和4 (Cu) 显示出针对Fusarium oxysporum f. sp.的显著抗真菌活性. 阿尔贝迪尼斯,表现优于自由带L.
结论:
- 这项研究成功地用1,2,4-三连接体合成和表征了新型金属复合物.
- 这些发现突显了超分子相互作用在晶体工程中的作用.
- 金属复合物显示出作为抗菌剂的巨大潜力,特别是针对特定的细菌和真菌病原体.
相关概念视频
Coordination Number and Geometry
15.9K
For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
15.9K
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
3.0K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
3.0K
Metal-Ligand Bonds
20.8K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
20.8K
Valence Bond Theory
8.6K
Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
8.6K
Complexometric Titration: Ligands
965
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
965
Coordination Compounds and Nomenclature
21.5K
In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
21.5K


![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)