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重视生物制药分类系统IIB药物的超和:通过多杯溶解方法和分子动态模拟进行评估

Yanxiong Gan1, Yaxin Xu1, Xue Zhang2,3

  • 1School of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Molecules (Basel, Switzerland)
|October 14, 2023
PubMed
概括

使用动态胃肠道模型 (DGIM) 的新溶解方法改善了基本药物的超和评估 (BCS IIB). 这种方法增强了可纳配方的体外-体内相关性 (IVIVC),有助于药物开发.

关键词:
溶解模型是一个溶解模型.在体外体内相对应的相关性分子动力学分子动力学降水抑制剂 降水抑制剂过度和是一种超和.

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