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Updated: Jul 13, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

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在区域选择性合成的NO-捐赠者 (4-Nitro-1,2,3-triazolyl) furoxans通过消除性亚胺-奥莱芬循环添加

Irina A Stebletsova1,2, Alexander A Larin1, Ivan V Ananyev3

  • 1N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russia.

Molecules (Basel, Switzerland)
|October 14, 2023
PubMed
概括

一种新的方法有效地使用循环添加化学制造酸酸. 这些化合物可以释放氧化 (NO),为新药开发提供了潜力.

关键词:
格雷斯测定方法没有捐赠者.这是一个循环加法循环.福洛克桑 (Furoxan) 是一种异循环是的不同循环.三醇三醇的使用方法

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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
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Treating arylamines with nitrous acid gives aryldiazonium salts that are effective substrates in nucleophilic aromatic substitution reactions. The diazonio group in these salts can be easily displaced by different nucleophiles, yielding a wide variety of substituted benzenes. The leaving group departs as nitrogen gas, and this easy elimination is the driving force for the substitution reaction.
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