赫斯佩里丁通过调节雌激素信号通路来预防骨质疏松症
Hong-Yao Hu1, Ze-Zhao Zhang2, Xiao-Ya Jiang2
1Jilin Medical Products Administration, Changchun 130000, China.
Molecules (Basel, Switzerland)
|October 14, 2023
概括
赫斯佩里丁是一种黄类化合物,通过激活雌激素信号通路,显示出对抗骨质疏松症的希望. 这种天然化合物促进骨形成并减少氧化应激,为这种常见疾病提供了潜在的治疗途径.
科学领域:
- 药理学和分子生物学
- 骨健康和骨质疏松症研究
- 自然产品治疗药物 自然产品治疗药物
背景情况:
- 骨质疏松症 (OP) 的特点是骨质减少和微型结构退化,导致骨折并影响生活质量,特别是在老年人群中.
- 黄胺对骨健康的好处的确切机制尚不清楚,需要进一步调查.
研究的目的:
- 使用网络药理学预测参与hesperidin抗骨质疏松作用的核心标和信号通路.
- 通过分子对接和动力学模拟来验证hesperidin与其预测目标之间的相互作用稳定性.
- 评估hesperidin对骨质母细胞功能和体内骨健康和氧化应激的影响.
主要方法:
- 网络药理学被用来确定hesperidin抗骨质疏松作用的关键标和途径.
- 分子对接和分子动力学模拟证实了hesperidin与已确定目标的结合稳定性.
- 在体外测试 (MTT,ELISA,ALP,RT-qPCR) 评估了hesperidin对MC3T3-E1骨质细胞的影响,而体内研究则使用斑马鱼模型.
主要成果:
- 网络药理学确定了10个关键目标,在雌激素信号通路中显著丰富.
- 素促进了MC3T3-E1细胞增殖,增强了性酸酶 (ALP) 活性,增加了氧化 (NO) 水平,并减少了促炎性细胞因子 (IL-6,TNF-α).
- 在体内,hesperidin促进了骨质生成,并减少了斑马鱼的氧化应激,分子动力学证实了对ESR1,SRC,AKT1和NOS3的稳定结合.
结论:
- 素可以通过ESR1激活雌激素信号通路来缓解骨质疏松症,通过ESR1升调SRC,AKT和eNOS,从而增加NO水平.
- 赫斯佩里丁促进骨质细胞介导的骨形成,并抑制促炎性细胞因子,有效降低骨质疏松症相关的氧化应激.
- 这些发现支持hesperidin作为一种潜在的治疗骨质疏松症的药物,向关键分子途径参与骨代谢和炎症.
相关概念视频
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Hormonal Regulation of the Menstrual Cycle
413
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
413
Major Hormones and Their Functions
457
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
457
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Regulation of Hormone Secretion
3.5K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
3.5K


