心率变量的最佳参数,用于评估刺激性肠综合征患者对短暂直肠阻塞的自主反应
M Khawar Ali1, Shiyuan Gong2, Borko Nojkov1
1Michigan Medicine, Department of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA.
Sensors (Basel, Switzerland)
|October 14, 2023
概括
交感指数 (SI) 和SDNN/SDNN指数是评估自主神经系统 (ANS) 对刺激性肠综合征 (IBS) 患者直肠膨胀反应的最敏感的心率变化 (HRV) 参数. 重复测试显示习惯,随着时间的推移减少了ANS反应.
科学领域:
- 自主神经科学 自主神经科学
- 胃肠病学 胃肠病学
- 心血管生理学心血管生理学
背景情况:
- 心率变化 (HRV) 是一种评估自主神经系统 (ANS) 活动的非侵入性方法.
- 刺激性肠综合征 (IBS) 与改变的ANS功能有关.
- 在IBS中,了解ANS对像直肠膨胀 (RD) 这样的内脏刺激的反应至关重要.
研究的目的:
- 为了确定最敏感和最强大的HRV参数来测量IBS患者在短暂的直肠膨胀期间的ANS活动.
- 评估重复的RD会议对ANS响应和HRV参数灵敏度的影响.
- 在IBS研究中提供实验设计的最佳实践信息,涉及重复的内脏刺激.
主要方法:
- 17名IBS患者在基线和逐步直肠膨胀 (高达60 mmHg) 期间进行了五次心电图记录.
- 计算了时间域,频域和非线性HRV参数,并在基线和RD条件之间进行了比较.
- 在五次会议中评估了HRV参数的灵敏度,稳定性和可重复性.
主要成果:
- 交感指数 (SI) 在检测ANS对RD的反应方面表现出最高的灵敏度和稳定性.
- SDNN和SDNN指数是最敏感的副交感参数,特别是在初始会话期间.
- 重复的RD会导致习惯,随着时间的推移,ANS反应减弱和HRV参数变化.
结论:
- SI和SDNN/SDNN指数是评估IBS中直肠张张的自主反应的最有效的HRV措施.
- 在IBS患者中,习惯性显著降低了对IBS患者重复的直肠张张的自主反应.
- 测试会话的随机化是必要的,以减轻重复的实验设计中的习惯效应.
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