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对与恶性转变风险相关的微RNA上口腔平坦的严重程度的分析

Alessandro Polizzi¹, Simona Santonocito¹, Alfio Distefano²

¹Department of General Surgery and Surgical-Medical Specialties, Unit of Periodontology, School of Dentistry, University of Catania, Catania, Italy.

|October 14, 2023

概括

口腔平 (OLP) 患者表现出改变的微RNA (miRNA) 表达,与恶性转变风险相关. 这些miRNA水平与OLP的严重程度相关,并预测临床结果.

科学领域:

口腔病理学口腔病理学
分子生物学分子生物学
生物化学生物化学

背景情况:

口腔平坦 (OLP) 是一种慢性炎症状况,有可能恶性转变.
微RNAs (miRNAs) 是小型非编码RNAs,调节基因表达,并与包括癌症在内的各种疾病有关.
了解OLP中的miRNA表达可能会为其病原和恶性进展提供洞察力.

研究的目的:

为了评估口腔组织表达特定的微RNAs (miRNAs) 在口腔平坦 (OLP) 的患者.
评估OLP严重程度与miRNA表达水平之间的相关性.
在OLP患者中确定miRNA表达的潜在预测因子.

主要方法:

该研究包括41名OLP患者和42名健康对照.
使用逆转录聚合酶链反应量化了miRNA水平 (miR-7a-3p, -7a-2-3p, -7a-5p, -21-3p, -21-5p, -100-3p, -100-5p, -125b-2-3p, -125b-5p, -200b-3p, -200b-5p) 的数量.
临床参数,症状,征兆和疾病严重程度得分通过历史调查问卷收集.

主要成果:

与对照组相比,OLP患者的miR-7a-3p, -7a-2-3p, -21-3p,miR-21-5p和miR-100-5p水平显著更高.
相反,OLP患者的miR-125b-2-3p, -125b-5p, -200b-3p和 -200b-5p水平显著降低.
OLP的症状,征兆和疾病严重程度得分与所有分析的miRNA显著相关,并预测了它们.

结论:

口服miRNA表达在OLP患者中是不平衡的,这表明与恶性演变风险的联系.
特定的miRNA与OLP的程度相关,并作为OLP症状,征兆和疾病严重程度的显著预测因素.

关键词:

生物标志物生物标志物疾病的严重程度.恶性疾病恶性疾病这是一个微型RNA.在口腔中,有平坦的海.预后预后预后

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