2型糖尿病加剧了牙周炎引起的牙髓病理变化
Tao Yang1, Bowen Zhou1, Zhaochen Shan1
1Outpatient Department of Oral and Maxillofacial Surgery, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China.
Oral diseases
|October 14, 2023
概括
糖尿病通过增加先进的糖化终产物 (AGEs) 和LOX1,导致炎症和细胞死亡,使牙周炎患者的牙髓损伤恶化. 早期的口腔护理对于糖尿病牙周炎患者至关重要.
科学领域:
- 口腔生物学 口腔生物学
- 牙周内脏病学 牙周内脏病学
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病和牙周炎对牙纸病理学的相互作用仍未得到充分研究.
- 了解这些机制对于管理患有这两种疾病的患者至关重要.
研究的目的:
- 探索糖尿病和牙周炎影响的牙纸病理变化.
- 阐明这些变化背后的分子机制.
主要方法:
- 从健康个人和患有牙周炎 (有或没有糖尿病) 的患者收集牙纸样本.
- 进行了形态分析,并评估了先进的糖化终产物 (AGEs),LOX1,氧化应激 (OS),炎症和亡.
主要成果:
- 糖尿病牙周炎 (DP) 组呈现稀疏,无序的脉结构和加厚的血管.
- 在DP患者中观察到AGEs和LOX1的升调,超氧化物脱酶2的降低,以及OS,炎症和亡的增加.
- 在DP组中,增加的骨质系统和炎症与增加的亡相关.
结论:
- 糖尿病在牙周炎中加剧牙纸病理,可能通过AGE和LOX1通道.
- 强调了糖尿病牙周炎患者早期口腔干预的重要性.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Pathophysiology of Diabetes
956
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
956
Diabetes: Symptoms, Diagnosis, and Complications
557
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
557
Carbohydrate Metabolism
11.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.2K
Diabetes Mellitus: Overview and Type I Subtype
2.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K
Teeth
460
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
460


