Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

211
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
211
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

503
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
503
Dementia01:30

Dementia

121
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
121
Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

4.5K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.5K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

126
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
126
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

283
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
283

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Recruitment strategies in a diverse Parkinson's disease cohort: lessons from the East London Parkinson's Disease Project.

BMJ neurology open·2026
Same author

Health and Social Care Interventions in the 80 years Old and Over Population: An Evidence and Gap Map.

Campbell systematic reviews·2026
Same author

The role of systemic microvascular function in the association between large artery stiffness and cognitive function in older adults.

Journal of hypertension·2026
Same author

Lifestyle interventions for dementia prevention in low- and middle-income countries: a systematic review.

BMJ global health·2026
Same author

Real-world use of lecanemab: patient pathway findings from a US multicenter study.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

The contribution of apolipoprotein E genetic variation to dementia risk in British South Asians.

Brain communications·2026
Same journal

Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Plasma-based neurobiological protein biomarkers as predictors of dementia progression: Insights from longitudinal aging study in India - Diagnostic assessment of dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Neuropathology-specific language features in primary progressive aphasia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Dementia blood biomarkers in the context of post-stroke cognitive outcomes: Systematic review and evidence synthesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jul 13, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K

人工智能用于预防痴呆症.

Danielle Newby1, Vasiliki Orgeta2, Charles R Marshall3,4

  • 1Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|October 14, 2023
PubMed
概括
此摘要是机器生成的。

人工智能和机器学习通过改进风险分析和临床试验招聘来提高痴呆症预防的前景. 这些技术可以个性化预防策略,加速治疗痴呆症的药物开发.

关键词:
人工智能的人工智能是人工智能.痴呆症 痴呆症是一种痴呆症.机器学习是机器学习.预防 预防 预防风险预测风险预测

更多相关视频

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage
06:46

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Published on: August 4, 2018

12.2K
Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

700

相关实验视频

Last Updated: Jul 13, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K
Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage
06:46

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Published on: August 4, 2018

12.2K
Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

700

科学领域:

  • 神经科学是一个神经科学.
  • 计算生物学 计算生物学
  • 公共卫生 公共卫生

背景情况:

  • 痴呆症预防研究已经确定了许多可修改的风险因素,但它们的相互作用和因果作用需要进一步调查.
  • 目前用于识别临床试验和药物开发的高风险个体的方法是不理想的.
  • 人工智能 (AI) 和机器学习 (ML) 提供了潜在的解决方案,以改进对痴呆风险因素的理解和应用.

研究的目的:

  • 探索机器学习 (ML) 方法在痴呆症预防中的应用.
  • 评估ML在痴呆症预防策略中的当前用途,局限性和未来潜力.
  • 突出人工智能如何提高痴呆风险管理和临床试验设计的精度.

主要方法:

  • 审查和讨论在痴呆症预防研究中示例机器学习 (ML) 应用.
  • 评估当前基于ML的风险分析和试验招聘工具的性能和局限性.
  • 分析AI和ML在药物重用和优先治疗方面的潜力.

主要成果:

  • 机器学习模型显示了开发改进的风险分析和临床试验招聘工具的潜力,可能降低成本并提高试验效率.
  • ML可以为药物重新定位提供信息,并有助于优先考虑痴呆症疾病修饰疗法.
  • 目前在痴呆症预防方面的ML应用有限,但该技术对未来的进步具有重大前景.

结论:

  • 机器学习 (ML) 准备在痴呆症预防中显著提高精度,尽管它尚未被广泛采用.
  • 人工智能可以个性化风险管理工具,并针对特定的患者群体进行临床试验,改善痴呆症预防结果.
  • 需要进一步的研究,以获得对终身痴呆症风险因素的因果洞察力,以便在预防工作中充分利用人工智能.