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Per-Unit Sequence Models

Per-Unit Sequence Models

An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...

Conservation of Protein Domains Over Different Proteins

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...

Sequence Networks of Rotating Machines

Sequence Networks of Rotating Machines

A Y-connected synchronous generator, grounded through a neutral impedance, is designed to produce balanced internal phase voltages with only positive-sequence components. The generator's sequence networks include a source voltage that is exclusively in the positive-sequence network. The sequence components of line-to-ground voltages at the generator terminals illustrate this configuration.
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Protein Families

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key...

Multi-species Conserved Sequences

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...

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Updated: Jul 13, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

蛋白质序列比较基于在有限维单位超立方体上的表示.

Soumen Ghosh^1,2, Jayanta Pal³, Carlo Cattani⁴

¹Electronics & Communication Engineering, National Institute of Technology, Durgapur, West Bengal, India.

Journal of biomolecular structure & dynamics

|October 14, 2023

概括

此摘要是机器生成的。

这项研究引入了一种使用物理化学性质进行蛋白质序列比较的新方法,产生准确的家族遗传树. 与现有方法相比,这种方法显示出更高的效率和理性的感知.

关键词:

关闭的WW 单一属性描述符 (SPD) 是一个单一属性描述符.一般化的NTV指标.物理化学性质物理化学性质排名相关系数的排名相关系数理性化的感知观念.对称的距离对称的距离.

更多相关视频

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

相关实验视频

Last Updated: Jul 13, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

科学领域:

生物化学生物化学
生物信息学是一种生物信息学.
计算生物学计算生物学

背景情况:

蛋白质序列比较对于理解生物功能和进化至关重要.
现有的方法通常依赖于复杂的算法,可能缺乏效率.
氨基酸的物理化学特性为序列分析提供了有价值的,但尚未被充分探索的基础.

研究的目的:

开发一种新的,高效的蛋白质序列比较和家族遗传树构建方法.
用单个物理化学性质值在高维空间中表示蛋白质序列.
评估拟议方法的准确性和效率与既有技术相比.

主要方法:

代表蛋白质序列作为基于单个物理化学性质值 (例如,极性,分子量) 的载体.
使用通用NTV度量来计算蛋白质序列之间的距离矩阵.
使用MEGA11软件中的邻居连接方法构建家族遗传树.
将该方法应用于各种数据集,包括线粒体蛋白质,转录因子,病毒和蛋白质激酶C家族成员.

主要成果:

来自不同单一属性值 (极性,分子量) 的遗传树是相同的,表明强度.
与基于对称距离和相关系数的现有方法相比,拟议的方法显示出更高的性能.
该方法在计算时间和合理化的感知方面实现了高效率.

结论:

基于物理化学性质的单一表示和通用的NTV指标为蛋白质序列比较提供了有效和高效的方法.
这种方法为植物遗传学分析提供了有价值的替代方案,在准确性和效率方面超过了以前的技术.
这些发现表明,这种方法在蛋白质的进化和功能研究中具有更广泛的适用性.