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品牌ferumoxytol与通用ferumoxytol在两个剂量方案中的比较:心脏MRI图像质量研究
Anoushka Dasi1,2, Donna N Kring1, Bhavani Selvaraj1
1Department of Radiology, Nationwide Children's Hospital, Columbus, OH, USA.
Pediatric radiology
|October 14, 2023
概括
通用ferumoxytol (GF) 和品牌ferumoxytol (BF) 在儿科心血管MR血管学和4D流量中显示出可比的安全性和图像质量. 降低剂量并没有影响诊断的准确性,这表明GF是一种可行的替代方案.
科学领域:
- 心血管成像 - 心血管成像
- 医学对比剂 医学对比剂
- 儿童心脏病学 儿童心脏病学
背景情况:
- 费鲁莫西托尔越来越多地用于儿科心血管MR血管造影 (MRA) 和4D流量成像.
- 品牌和通用ferumoxytol都可用,但缺乏关于疗效和安全性的比较数据.
研究的目的:
- 为了评估患者的安全性和图像质量,一般性ferumoxytol (GF) 与可比剂量的品牌ferumoxytol (BF) 相比.
- 测试将对比剂量从3降至2mg/kg是否会影响成像质量和诊断准确度.
- 为了确定GF和BF是否表现出类似的图像质量和安全配置文件.
主要方法:
- 对3组的回顾性分析:儿童和成人心脏病患者的3毫克/千克BF (n=216),2毫克/千克BF (n=47) 和2毫克/千克GF (n=127).
- 评估生命标志和临床状况的变化,不良反应 (轻度,中度,严重) 和MR图像质量 (MRA的SNR,4D流量的VNR).
- 定量和定性图像分析,使用ANOVA和千平方测试 (P≤0.05显著性) 进行统计比较.
主要成果:
- 两组之间没有观察到临床状况或生命体征的显著差异 (P>0.05).
- 7.9%的GF患者,2.3%的3mg/kgBF患者和8.4%的2mg/kgBF患者出现了不良反应,没有报告严重反应.
- 对于MRA,SNR没有统计差异;然而,2 mg/kg GF与2 mg/kg BF (P=0.005) 相比,对4D流量显示VNR增加. 所有组的质量分数都很高.
结论:
- 通用ferumoxytol (GF) 和品牌ferumoxytol (BF) 在2mg/kg剂量时显示出类似的安全性和图像质量.
- 降低对比剂量 (2 mg/kg) 并没有影响MRA或4D流图像质量.
- 由于研究的样本规模有限,建议进行进一步的研究以证实这些发现.
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