药用植物的全基因组测序:目前的进展和前景
Yifei Pei1, Liang Leng2,3, Wei Sun1
1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Science China. Life sciences
|October 14, 2023
概括
药用植物的基因组研究正在推进,但多倍积分症等挑战阻碍了高质量的基因组测序. 本综述分析了123个已发表的基因组,并提出了未来高质量测序的策略.
科学领域:
- 基因组学就是基因组学.
- 植物科学 植物科学
- 医学植物学 医学植物学
背景情况:
- 基因组学的进步加速了药用植物研究",1K药用植物基因组项目"旨在解码它们的遗传构成.
- 获得高质量的全基因组是具有挑战性的,因为药用植物的多重性和高异构性.
- 50个国家的1000多个机构都参与了药用植物基因组研究,到2022年9月将有123个基因组发表.
研究的目的:
- 审查和分析已发表的药用植物基因组序列.
- 为了识别分类的趋势,研究小组, ploidy,药用功能,和测序策略.
- 为获得高质量的药用植物基因组提出明确的战略,并倡导建立一个模型植物研究平台.
主要方法:
- 对123个已发表的药用植物全基因组序列进行系统审查.
- 数据分析,包括物种分类,研究机构,性水平,药用功能和测序方法.
- 综合文献,以确定挑战,并为未来的研究提出战略框架.
主要成果:
- 二倍体物种构成了大多数被测序的药用植物,其中科是最受研究的.
- 大约40%的研究集中在具有调,补充和清洁热量的药用特性的物种上.
- 药用植物与作物不同,通常缺乏纯线,并具有不清楚的遗传背景,使基因组组复杂化.
结论:
- 对于高质量的药用植物基因组测序,需要一个标准化的策略.
- 对全基因组基因繁殖和生物合成的进一步研究至关重要.
- 建立一个模型药用植物研究平台将大大推动草本基因组学领域的发展.
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