在艾滋病毒感染者中预防乙型肝炎病毒的策略
Maria A Corcorran1, H Nina Kim2
1Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA. corcom@uw.edu.
乙型肝炎病毒 (HBV) 疫苗接种策略对于感染艾滋病毒 (PLWH) 的人来说至关重要. 更新的疫苗接种方案和化疗预防可以提高这一脆弱人群的HBV血清保护率.
科学领域:
- 传染性疾病 传染性疾病
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 人类免疫缺陷病毒 (HIV) 和乙型肝炎病毒 (HBV) 的同时感染是普遍存在的,因为它们有共同的传播途径.
- 艾滋病毒-HBV共感染加速肝病的进展.
- 在艾滋病毒感染者 (PLWH) 接受标准HBV疫苗接种时,血清保护率历史上较低.
研究的目的:
- 审查目前在PLWH中预防HBV的战略.
- 专注于最近HBV疫苗接种和PLWH的化疗预防的最新更新.
主要方法:
- 审查最近的研究和临床指导方针.
- 疫苗接种疗效和化疗预防措施的分析.
- 评估ART疗法及其对HBV保护的影响.
主要成果:
- 增强的HBV疫苗接种策略,包括双剂量疫苗 (例如,Heplisav-B),在PLWH中显示出改善的血清保护.
- 含有特诺福维尔的抗逆转录病毒疗法 (ART) 提供了一些HBV保护,但这种保护可能会随着特诺福维尔节制或长效疗法而丧失.
- 所有感染艾滋病毒的HBV敏感个体都需要接种疫苗,不论其ART治疗方案或CD4计数如何.
结论:
- 优化HBV疫苗接种对于PLWH至关重要.
- 需要仔细考虑ART疗法,以保持HBV的保护.
- 全球HBV疫苗接种是所有艾滋病毒感染者的建议.
更多相关视频
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
09:35Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
相关概念视频
Retrovirus Life Cycles
Sexually Transmitted Infections
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Viruses with RNA Genomes
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
