与医院对照组相比,Pseudoxanthoma elasticum患者在计算机断层扫描上结石的患病率更高吗?
Iris M Harmsen1, Madeleine Kok2, Jonas W Bartstra2
1Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
Clinical and experimental nephrology
|October 14, 2023
概括
这项研究发现,石患病率在pseudoxanthoma elasticum (PXE) 患者和对照组之间没有显著差异. 需要进一步的研究来了解PXE的宫外化风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 遗传学 遗传学 是一个
- 放射学 放射学是一门学科.
背景情况:
- 伪松 (Pseudoxanthoma elasticum,简称PXE) 是一种与血中低酸盐 (PPi) 相关的自体衰退性疾病,它是一种化抑制剂.
- 在PXE中降低的PPi水平可能会使个体易患子宫外化,包括结石.
- 这项研究调查了PXE与结石形成之间的潜在关联.
研究的目的:
- 为了比较PXE患者中结石的患病率与对照组.
- 利用计算机断层扫描 (CT) 成像来准确检测和评估石头.
- 在PXE的背景下分析与结石形成相关的风险因素.
主要方法:
- 273名PXE患者和125名对照者的低剂量CT扫描被盲目放射科医生审查.
- 记录了结石的患病率,数量和大小.
- 使用多变量逻辑回归来计算赔率比率,并根据年龄和性别进行调整.
主要成果:
- 结石的患病率在PXE患者 (6.9%) 和对照 (5.6%) 之间是相似的.
- 两组之间没有观察到结石患病率的统计学上显著差异 (p=0.6).
- 调整后的分析显示,PXE患者结石的几率没有显著增加 (OR 1.48;95% CI 0.62-3.96).
结论:
- 与对照组相比,在PXE患者中CT检测到的偶发结石的患病率没有显著差异.
- 这些发现表明,PXE中的血PPi降低可能不会显著增加结石形成的风险.
- 对PXE中其他潜在的宫外化部位的进一步调查是有必要的.
关键词:
ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC6ABCC这就是为什么CTCTCTCTCTCT计算机断层扫描 (CT) 是一种计算机断层扫描.结石 结石是指结石的出现.在PXE中,PXE是PXE.伪索索马弹性 (Pseudoxanthoma elasticum) 是一种类型的虫.乌罗石质病是一种质病.
相关概念视频
01:27Imaging Studies III: Computed Tomography
12
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
12
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
13
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
13
01:30Urinary Tract Calculi III: Medical Management
9
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
9
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
11
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
11
01:28Urinary Tract Calculi I: Introduction
16
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
16
01:28Imaging Studies I: Kidney, Ureter, and Bladder Studies
11
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
11