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暴露于多重多芳香碳化合物和牙周炎之间的关联:来自横截面研究的发现

Fei Lin¹, Huaicheng Wang², Xuefei Wang²

¹Department of Stomatology, Fujian Medical University Union Hospital, Fuzhou, 35001, China.

Environmental science and pollution research international

|October 14, 2023

概括

对多重多环芳 (PAH) 的暴露与美国成年人牙周炎风险增加有关. 血液中性粒细胞部分调解了特定PAHs的这种关联,突出了潜在的生物途径.

科学领域:

环境健康环境健康
牙周病学牙周病学
毒理学毒理学毒理学

背景情况:

环境污染物,特别是多环芳 (PAH),越来越多地被认为对健康有不利影响.
暴露于多种PAH和牙周炎 (一种常见的炎症性牙疾病) 之间的关联仍然不完全理解.

研究的目的:

调查美国成年人群中暴露于六种特定PAH混合物和牙周炎之间的关系.
探索生物因素,如血液中性粒细胞在这种协会中的潜在调解作用.

主要方法:

利用了1880名参与国家健康和营养检查调查 (NHANES) 的数据.
测量了六种PAHs的尿度:1-氧纳甲烯 (1-OHN),2-氧纳甲烯 (2-OHN),3-氧烯 (3-OHF),2-氧烯 (2-OHF),1-氧烯 (1-OHPhe) 和1-氧烯 (1-OHPyr).
采用多重物流回归,受限立方线和贝叶斯内核机器回归 (BKMR) 模型进行统计分析,包括调解分析.

主要成果:

在多重PAH的较高水平和牙周炎风险增加之间观察到显著的积极关联.
像2-OHN,3-OHF,2-OHF,1-OHPhe和1-OHPyr这样的特定PAHs在更高暴露四分位数中显示牙周炎的几率增加.
BKMR证实了PAH混合物和牙周炎之间的积极关系,血液中性粒细胞被确定为3-OHF和2-OHF的部分媒介.

结论:

对多种PAH的暴露与美国成年人的牙周炎有关.
血液中性粒细胞在某些PAHs (3-OHF,2-OHF) 和牙周炎之间的关系中起着调解作用,这表明一种潜在的作用机制.

关键词:

BKMR BKMR 在线播放尼汉斯 (NHANES) 是一个名人.牙周病是指牙周病的发生.多芳香的碳化合物聚芳香的碳化合物

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