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相关概念视频

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Signal processing techniques are essential for accurately converting continuous signals to digital formats and vice versa. When a continuous signal is sampled with a period T, the resulting sampled signal exhibits replicas of the original spectrum in the frequency domain, spaced at intervals equal to the sampling frequency. To handle this sampled signal, a zero-order hold method can be applied, which creates a piecewise constant signal by retaining each sample's value until the next...
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Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
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相关实验视频

Updated: Jul 13, 2025

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
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双能量CT重建使用受约束的一步光谱图像重建算法.

Benjamin M Rizzo1, Emil Y Sidky2, Taly Gilat Schmidt1

  • 1Department of Biomedical Engineering, Marquette University and the Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Medical physics
|October 14, 2023
PubMed
概括

受约束的一步光谱CT图像重建 (cOSSCIR) 方法准确地从双kV数据重建材料基图. 这种光谱CT成像技术显示出改善量化和临床应用的前景.

科学领域:

  • 医疗成像医学成像
  • 计算成像技术的成像
  • 材料科学 材料科学 材料科学

背景情况:

  • 受约束的一步光谱CT图像重建 (cOSSCIR) 方法从光谱CT数据估计基础材料图.
  • 它采用多能X射线传输模型和凸约束来实现稳定的反转.
  • cOSSCIR适用于双能CT系统,包括快/慢kV切换和双源扫描仪.

研究的目的:

  • 调查cOSSCIR对双kV光谱CT数据的应用.
  • 通过注册和未注册的频谱采集 (缓慢和快速kV切换) 来评估cOSSCIR.
  • 这项研究标志着cOSSCIR用于双kV重建的首次演示.

主要方法:

  • 开发了一种用于双kV数据重建的集成探测器模型.
  • 验证了探测器模型,使用与盆腔幻影的反向犯罪模拟.
  • 将cOSSCIR应用于与骨,脂肪和肝脏组织类似物的物理幻影实验.
  • 将cOSSCIR与传统的图像域分解方法进行比较.

主要成果:

  • 模拟成功恢复了材料基础地图,突出了未注册数据的挑战.
  • 实验重建显示,在注册/未注册的协议中,骨,脂肪和肝脏基底图的误差为<6.5%.
关键词:
双能量和光谱CTCT的使用.图像重建 图像重建定量成像技术 定量成像技术

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  • 50keV的虚拟单能图像有<4%的误差,分解向量与地面真相密切匹配.
  • 初步的量化结果显示,的平均度为9.2 mg/mL.

    • 结论:

    • cOSSCIR可以准确地从双kV数据中恢复材料基础地图,无论登记或成像协议如何.
    • 材料分解量化与图像域方法相比较有利.
    • 结果表明cOSSCIR有可能通过两种材料分解量化.