低血清25-基维生素D水平与多发性硬化症的认知障碍有关
Antonio Luca Spiezia1, Fabrizia Falco1, Andrea Manganelli1
1Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, Italy.
Multiple sclerosis and related disorders
|October 14, 2023
概括
维生素D水平较低与多发性硬化症 (MS) 患者的认知功能较差有关. 这项研究强调了维生素D对于维持MS患者认知健康的重要性.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 认知障碍是患有多发性硬化症 (MS) 的人面临的常见挑战.
- 低维生素D水平已与各种神经退行性疾病中的认知功能障碍有关.
- 在MS中,维生素D缺乏也与运动残疾和疾病活动有关.
研究的目的:
- 调查血清25- (25-OH) 维生素D水平与多发性硬化症患者的认知状态之间的关联.
- 为了确定维生素D水平是否与MS中使用的特定认知测试的表现相关.
主要方法:
- 进行了一项涉及181名多发性硬化患者的横截面研究.
- 测量了血清25-OH维生素D水平,并使用MS简要国际认知评估 (BICAMS) 评估认知功能,包括符号数字模式测试 (SDMT),加利福尼亚口语学习测试-II (CVLT-II) 和简要视觉空间记忆测试-修订 (BVMT-R).
- 人口统计,临床变量和心理健康评估 (抑郁,焦虑,疲劳) 被收集用于分析.
主要成果:
- 较低的血清25-OH维生素D水平与所有BICAMS认知测试的表现差显著相关.
- 发现维生素D水平与SDMT,CVLT-II和BVMT-R.得分之间存在正相关性.
- 维生素D水平与扩展残疾状况尺度 (EDSS) 相反相关,表明与残疾严重程度的联系.
结论:
- 血清25-OH维生素D的降低与MS患者的认知功能受损有关.
- 这些发现表明,维持足够的维生素D水平可能对MS患者的认知健康很重要.
- 未来的研究应该探索维生素D补充对MS患者认知功能的长期影响.
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