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白质在复发缓解多发性硬化症患者认知障碍中的作用

Mahmoud Elkhooly¹, Fen Bao², Muhammad Raghib²

¹Neurology Department, Wayne State University, Detroit, MI 48201, USA; Department of Neurology and Psychiatry, Minia University, Minia, Egypt.

Multiple sclerosis and related disorders

|October 14, 2023

概括

复发性缓解性多发性硬化症 (RRMS) 的认知障碍与白质损伤有关. 特定的白质通道,如上大脑小脚,在RRMS患者中显著影响认知功能.

科学领域:

神经科学是一个神经科学.
放射学放射学是指放射学
认知科学认知科学

背景情况:

多发性硬化症 (MS) 的认知障碍通常归因于灰质损伤,白质 (WM) 的贡献被理解得更少.
这项研究研究了复发性缓解性多发性硬化症 (RRMS) 患者的认知功能和特定WM通道之间的关系.

研究的目的:

检查RRMS患者的认知表现和白质完整性之间的关联.
确定与RRMS认知缺陷相关的特定白质道.

主要方法:

30名RRMS患者接受了认知测试 (PASAT-3,SDMT) 和全脑MRI与扩散张力成像 (DTI).
在37个WM区域分析了DTI参数 (分数不均度 - FA,平均扩散度 - MD),使用人类连接体项目地图和DSI工作室.
斯皮尔曼的等级相关性和虚假发现率被用来分析WM通道完整性和认知得分之间的关系.

主要成果:

较高的FA值与更好的认知表现相关,而较高的MD值与较差的认知功能相关.
在右侧中间和上大脑和SDMT分数中发现了FA之间的正相关性.
在上大脑脚,左弧形囊,左极端囊和SDMT得分中的MD之间观察到负相关性. PASAT-3得分显示了与右小脑中MD的负相关性.

结论:

白质道,特别是上大脑脚,在RRMS的认知障碍中发挥着重要作用.
需要进一步的纵向研究以更大的样本大小来证实这些发现,并了解MS认知衰退的进展.

关键词:

认知障碍认知障碍是一种认知障碍.多发性硬化症是多发性硬化症.在PASAT-3中使用PASAT-3.SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT SDMT 白质通过白质的轨道.

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