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身体活动与内皮功能障碍的关联在患有和没有慢性病的成年人中:马斯特里赫特研究
Ioannis Bellos1, Smaragdi Marinaki2, Pagona Lagiou3
1Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Greece; Department of Nephrology and Renal Transplantation, Laiko General Hospital, National and Kapodistrian University of Athens, Greece.
Atherosclerosis
|October 14, 2023
概括
身体活动 (PA) 与正常功能和慢性病 (CKD) 患者的更好的内皮功能 (ED) 有关. 长时间的久坐活动与CKD患者的ED增加有关.
科学领域:
- 心血管疾病的研究研究.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 运动生理学 运动生理学
背景情况:
- 身体活动 (PA) 是心血管疾病的已知保护因素.
- 久坐不动行为 (SB) 是心血管疾病的一个新兴的独立风险因素.
- 内皮功能障碍 (ED) 是心血管疾病发展的关键因素.
研究的目的:
- 评估身体活动 (PA) 和久坐行为 (SB) 与内皮功能障碍 (ED) 之间的关联.
- 检查这些关联与功能状态有关,包括正常功能和慢性病 (CKD).
主要方法:
- 利用来自前性,基于人口的马斯特里赫特研究的横截面数据.
- 使用ActivPAL3加速度计在连续八天测量PA和SB.
- 通过特定生物标志物的血水平来评估ED,并结合成ED分数.
主要成果:
- 在具有正常功能的人群中,ED得分与总,低强度和中度至强度的PA持续时间有负相关性.
- 在正常功能个体中,ED得分与总久坐时间,久坐休息时间和久坐时间持续时间有关.
- 在患有慢性病 (CKD) 的参与者中,ED得分与总和低强度PA持续时间负相关,与久坐性发作持续时间正相关.
结论:
- 在正常功能和CKD群体中,PA持续时间与ED相反相关.
- 长时间的久坐活动与患有CKD的个体内皮质功能障碍的增加显著相关.
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