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嵌合式抗原受体T细胞疗法后的认知:系统性审查

Christina Kazzi¹, Valeriya Kuznetsova², Pakeeran Siriratnam¹

¹Department of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, Central Clinical School, Monash University, Melbourne, VIC, Australia; Department of Neurology, Alfred Health, Melbourne, VIC, Australia.

Journal of autoimmunity

|October 14, 2023

概括

在仿真抗原受体T细胞治疗后,认知副作用很常见,大多数急性缺陷在几周内消失. 然而,一些患者长期经历持续的认知问题,需要进一步研究.

科学领域:

在瘤学瘤学.
神经科学是一个神经科学.
免疫学免疫学免疫学

背景情况:

化学抗原受体 (CAR) T细胞疗法是一种新的癌症治疗方法.
了解其对认知功能的影响对于患者护理至关重要.

研究的目的:

系统地审查和描述接受CAR T细胞治疗的患者的认知结果.

主要方法:

在多个数据库 (PubMed,PsycINFO,SCOPUS,EMBASE,Medline,CINAHL) 进行了全面的文献搜索,截至2023年2月.
使用已建立的案例报告和非随机研究工具来评估偏差风险.

主要成果:

包括22项涉及1104名参与者的研究,显示出显著的方法异质性.
认知结果各不相同,一些患者随着时间的推移表现出稳定,改善或减少的认知能力.
认知症状在急性阶段 (输注后<2周) 频繁出现,大多数在1-2周内消失,但有一部分人经历了持续的缺陷.

结论:

在CAR T细胞治疗后,认知症状是一个值得关注的问题,特别是在急性阶段.
虽然许多急性缺陷是短暂的,但在一小部分患者中会出现持续的认知问题.
建议在急性,亚急性和慢性阶段采用联合自我报告和心理测量措施进行进一步的研究.

关键词:

化学抗原受体T细胞治疗认知认知是一种认知.血液学癌症是一种血液学癌症.神经毒性神经毒性

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