感知受体在正常和异常甲状腺和甲状腺组织上的表达
Anne L Worth1, Mesrop Ayrapetyan2, Susan J Maygarden2
1School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
The Journal of surgical research
|October 14, 2023
概括
感应受体 (CaSR) 在副甲状腺表达高,使其成为改善放射检测的有希望的目标. 这个受体这个受体.
科学领域:
- 生物化学 生物化学
- 放射学 放射学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 目前的副甲状腺成像方法面临显著的局限性.
- 感应受体 (CaSR) 被探索为副甲状腺成像的新型分子标.
- 差异表达对于准确的成像目标与相邻组织至关重要.
研究的目的:
- 在正常和异常甲状腺组织中调查CaSR的相对丰度.
- 为了比较甲状腺侧腺组织中的CaSR表达与正常和异常的甲状腺组织.
- 评估CaSR作为一种潜在的目标,用于对甲状腺腺体的特定放射检测.
主要方法:
- 利用现有的临床样本病理确认的甲状腺和副甲状腺组织.
- 在组织段上进行了对CaSR的免疫组织化学染色.
- 使用H分数 (强度x细胞百分比) 来量化CaSR表达.
主要成果:
- 所有甲状腺样本都表现出高的CaSR表达 (正常:H分数271,异常:H分数38.3).
- 甲状腺癌表现出差异性的CaSR表达 (骨髓: 182,赫尔特尔细胞:101),明显高于正常甲状腺,但低于副甲状腺.
- 与正常甲状腺组织相比,甲状腺侧腺组织中的CaSR表达显著更高 (P < 0.001).
结论:
- 感应受体 (CaSR) 在甲状腺组织中具有差异性表达,使其成为甲状腺成像的可行目标.
- 在成像中存在虚假阳性的潜力,这是由于甲状腺髓细胞和赫尔特尔细胞癌症中的CaSR表达.
- 准CaSR提供了一个有前途的途径,可以增强对甲状腺腺的放射检测.
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