在活性肺结核中微RNA-29a的诊断性能:系统性审查和元分析
Xiaoying Li1, Yuehong Xu2, Pu Liao1
1Department of Clinical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, China.
Clinics (Sao Paulo, Brazil)
|October 14, 2023
概括
微RNA-29a (miRNA-29a) 作为诊断活跃结核病的生物标志物非常有前途. 这一元分析证实了其诊断价值,其综合灵敏度为78%,特异性为76%.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 新兴研究表明microRNA-29a (miRNA-29a) 是活跃结核病的潜在生物标志物.
- 目前关于miRNA-29a对结核病的诊断价值的研究结果不一致.
研究的目的:
- 进行全面的元分析,评估miRNA-29a对活跃结核病的诊断准确性.
- 巩固现有证据,并更清楚地了解miRNA-29a在结核病诊断中的实用性.
主要方法:
- 在主要数据库 (CNKI,WanFang,PubMed,Cochrane Library,Web of Science,EMBASE) 进行系统的文献搜索.
- 包含/排除标准选和使用 QUADAS-2 尺度进行质量评估.
- 使用Meta-DiSc 1.4和Stata 16.0软件进行的元分析.
主要成果:
- 包括13篇文章,包括1598名受试者 (872名活跃结核病患者,726名对照).
- 对miRNA-29a的综合诊断灵敏度为78%,特异性为76%.
- 总结接收器操作特征曲线 (AUC) 下的面积为0.8564.4.
结论:
- 微RNA-29a显示出作为活跃结核病的诊断生物标志物的显著潜力.
- 分析支持miRNA-29a在临床环境中用于结核病检测的使用.
- 进一步的研究可能会完善miRNA-29a在结核病诊断中的作用.
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