多样化的非洲基因组揭示了在尼安德特人中古代现代人类侵入的选择
Daniel N Harris1, Alexander Platt1, Matthew E B Hansen1
1Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Current biology : CB
|October 14, 2023
概括
撒哈拉以南非洲地区的尼安德特人DNA揭示了古代人类从非洲迁移,以及尼安德特人和解剖学上现代人类 (AMH) 之间的双向基因流动. 这种内向突出了早期的进化相互作用和初始的物种化.
科学领域:
- 古遗传学是古遗传学的一部分.
- 人类进化人类进化
- 人口遗传学 人口遗传学
背景情况:
- 对比揭示了尼安德特人-AMH在非非洲人群中的侵入,这是由于古代的杂交.
- 撒哈拉以南非洲人群中的尼安德特人遗传相似性起源不明.
- 了解这些区域可以告知早期人类和尼安德特人的进化.
研究的目的:
- 研究撒哈拉以南非洲尼安德特人基因组区域的分布和起源.
- 澄清古代人类迁徙和尼安德特人的混合在塑造非洲基因组中的作用.
- 分析基因组数据以了解早期人类和尼安德特人的进化动态.
主要方法:
- 来自12个撒哈拉以南非洲人口的180个个体的全基因组测序.
- 在非洲基因组中分析尼安德特人同类区域.
- 进行比较基因组学,以评估入侵模式和祖先.
主要成果:
- 撒哈拉以南非洲人最近非非洲血统显示高达1%的尼安德特人DNA来自后来的混合事件.
- 撒哈拉以南非洲人中的大多数尼安德特人DNA源自早期的AMH迁移出非洲 (∼250 kya) 和随后的混合.
- 在AMH基因组中的尼安德特人DNA和尼安德特人基因组中的AMHDNA的枯竭表明了有害的相互作用,表明了初始的物种化.
结论:
- 从非洲出发的多个AMH迁移事件发生了,尼安德特人和AMH之间有双向基因流动.
- 基因组模式揭示了尼安德特人和AMH的内进DNA的负选择.
- 这些发现提供了对早期人类分散和原始人群的进化分歧的见解.
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