虚拟现实工作记忆训练改善了严重抑郁症患者的急性和缓解患者的认知表现
Shuya Yan1, Shiyi Shen2, Qianyi Lu3
1Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Journal of affective disorders
|October 14, 2023
概括
虚拟现实工作记忆 (VR-WM) 训练显著改善了主要抑郁症 (MDD) 患者的认知功能. 这种VR-WM干预也有助于减少抑郁症状,提高整体认知表现.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 人与计算机的交互
背景情况:
- 大型抑郁症 (MDD) 与显著的神经心理障碍有关.
- 虚拟现实 (VR) 为认知训练,特别是工作记忆 (WM) 提供了一个新的平台.
- 对于MDD患者的认知缺陷,基于VR的WM培训存在有限的研究.
研究的目的:
- 确定VR-WM培训在急性和缓解性MDD患者中的有效性.
- 调查VR-WM培训对认知表现的影响背后的潜在机制.
- 评估VR-WM培训对各种认知领域和抑郁症状的影响.
主要方法:
- 42名MDD患者 (22例急性,20例缓解) 接受了20次VR-WM培训.
- 22名健康对照没有接受任何干预.
- 认知表现 (WM,处理速度等) 使用标准化措施 (CPFQ,MCCB,24-HDRS) 评估了干预前和后的抑郁症状.
主要成果:
- 无论是急性MDD患者还是缓解MDD患者,在训练后的WM,处理速度,视觉学习,推理,问题解决和整体认知都有显著的改善 (p <0.05).
- 在抑郁症状得分 (24-HDRS) (p < 0.05) 中观察到显著改善.
- 调解分析表明,抑郁症状的减少部分解释了WM和总认知的改善.
结论:
- 在急性和缓解的MDD患者中,VR-WM培训有效提高认知功能,包括WM.
- 在MDD患者中VR-WM训练的认知益处部分是由抑郁症状的改善介导的.
- VR-WM 培训为解决重大抑郁症中认知障碍提供了一个有前途的治疗工具.
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