低频波动与双相情感障碍患者的认知表现之间的相关性 自杀念头
Shixuan Feng1, Sumiao Zhou1, Yuanyuan Huang2
1Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Journal of affective disorders
|October 14, 2023
概括
患有双相情感障碍和自杀念头的患者表现出与认知缺陷相关的大脑功能异常. 这项研究将前皮质和带皮质中的大脑活动与这些患者的认知表现联系起来.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 双极性障碍 (BD) 患者面临自杀念头 (SI) 的高风险.
- 自杀念头在BD (BDSI) 与异常的自发大脑功能有关.
- 认知障碍是BD的核心症状,但其与BDSI中大脑功能之间的联系尚未得到充分研究.
研究的目的:
- 为了研究认知表现和自发大脑功能之间的关联,在BD患者自杀念头 (BDSI).
- 为了在BDSI,无自杀念头的BD (BDNSI) 和健康的对照组 (HC) 中比较认知表现和大脑功能.
主要方法:
- 使用MATRICS共识认知电池 (MCCB) 评估认知表现.
- 通过静止状态功能磁共振成像 (rs-fMRI) 测量自发大脑活动,以获得低频波动 (ALFF) 幅度值.
- 在BDSI,BDNSI和HC组中,MCCB得分和ALFF值之间的相关性分析.
主要成果:
- 与HC患者相比,BDSI患者在左前皮质和右后皮带皮质中显示出更高的ALFF.
- 与HC相比,BDNSI患者在右前肌中表现出较低的ALFF.
- 在BDSI患者中,视觉学习表现与左前肌中的ALFF正相关.
结论:
- 双极性障碍患者表现出异常的ALFF.
- 这些脑功能异常与BDSI患者的认知表现有关.
- 研究结果强调了自发大脑活动和自杀意念的BD患者的认知缺陷之间的关系.
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