CWC22-Spp1中介的替代拼接调节炎性疼痛中的知觉

Yu Song1, Zhi-Yong Wang2, Jun Luo3

  • 1Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu Province 221004, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, Jiangsu Province 221004, China; Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province 221002, China.

Neuroscience
|October 14, 2023
PubMed
概括

这项研究表明,脊髓中CWC22的升高通过改变Spp1 V4拼接来驱动炎症性疼痛. 减少CWC22减轻疼痛,建议它作为慢性疼痛条件的治疗目标.

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