主性组织相容性复合II表达在口腔朗格汉斯细胞上 不同调节粘膜CD4和CD8T细胞
Lori A Fischer1, Peter D Bittner-Eddy1, Massimo Costalonga1
1Division of Basic Sciences, Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.
The Journal of investigative dermatology
|October 14, 2023
概括
在口腔粘膜中,兰格汉斯细胞 (LC) 呈现的主要组织相容性复合体II类 (MHC-II) 维持了CD4 T细胞的反应,但残留的LC可以促进CD8 T细胞的监测. 这一发现影响了对粘膜免疫的理解.
科学领域:
- 免疫学 免疫学 免疫学
- 口腔粘膜免疫力 免疫力
- T细胞生物学T细胞生物学
背景情况:
- 朗格汉斯细胞 (LCs) 是口腔粘膜中的关键抗原呈现细胞.
- LCs在T助手17 (Th17) 细胞对口腔病原体 (如 Porphyromonas gingivalis) 的反应中发挥作用.
- 在T细胞群体上口服LCs表现的主要基因相容性复合体II类 (MHC-II) 的确切功能尚不清楚.
研究的目的:
- 研究LC特异性MHC-II呈现对口腔粘膜T细胞反应的影响.
- 为了确定口腔LCs上减少的MHC-II表达是否会影响Th17细胞稳态和CD8T细胞扩张.
主要方法:
- 通过使用人类-朗格林促进剂-Cre系统生成了一种具有LC特异性删除H2-Ab1 (MHC-II) 基因的小鼠模型.
- 量化MHC-II表达在口腔和皮肤LCs.
- 在野生型和淘汰赛小鼠的口腔粘膜中分析了CD4,Th1,Th17,Helios+T调控和CD8T细胞群.
- 在带诱导的牙周炎模型中研究了T细胞的反应.
主要成果:
- MHC-II在口服居民LC的81.2%中被消去,对CD4 T细胞数量或Th17细胞频率的影响很小.
- 在小鼠中观察到Th1细胞的减少和Helios+ T调节细胞的增加,小鼠的LC MHC-II减少.
- 尽管LCs上的MHC-II减少了,但在牙周炎期间,Th17细胞数量保持不变.
- 在缺乏显著LC MHC-II表达的小鼠中,口腔粘膜CD8 T细胞增加了25倍以上.
结论:
- 在口腔粘膜中,MHC-II表达的LCs的小群体足以维持同居的CD4 T细胞反应.
- 具有MHC-II呈现的残留LC不足以抑制CD8 T细胞的局部扩张.
- 在特定的LC亚群中减少MHC-II表达可能会增强CD8介导的粘膜表面内皮质监测.
相关概念视频
T Cell Activation and Clonal Selection
774
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
774
Antigens Involved in Adaptive Immunity
512
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
512
Antigen Processing Pathways
1.0K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
1.0K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Cell-mediated Immune Responses
68.6K
Overview
68.6K
B Cell Activation and Differentiation
1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.8K


