加强与癌症相关的肺栓塞的标准化抗凝药:来自单一中心的真实世界数据
Mingjie Liu1, Xianming Qiu2, Yuanyuan Sun1
1Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China.
Clinical therapeutics
|October 14, 2023
概括
患有肺栓塞 (PE) 的癌症患者通常接受较短的抗凝治疗,导致复发性静脉血栓栓塞 (VTE) 的风险显著增加. 标准化治疗对于改善癌症相关PE的结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 肺栓塞 (PE) 是癌症患者的主要死亡原因.
- 抗凝药是癌症相关PE的标准治疗方法,但在现实实践中往往未得到充分利用.
研究的目的:
- 调查非最佳抗凝剂治疗对癌症相关PE预后的影响.
- 评估PE癌症患者抗凝时间和结果之间的关系.
主要方法:
- 分析了356名新诊断急性PE患者的队列.
- 结果包括复发性静脉血栓塞栓症 (VTE),全因死亡率和严重出血.
- 使用考克斯回归分析来确定复发性VTE的危险因素.
主要成果:
- 与非癌症患者相比,癌症患者 (43.8%) 接受的抗凝剂较少,时间较短.
- 癌症患者的复发性静脉瘤发病率 (17.3%对4.0%) 和全因死亡率 (23.7%对10.5%) 较高.
- 在癌症患者中,在3个月后停止抗凝药显著增加了复发静脉瘤的风险 (HR, 15.815).
结论:
- 低于最佳的抗凝血持续时间在与癌症相关的PE中很常见.
- 较短的抗凝治疗与更糟糕的预后有关,特别是复发性VTE的更高率.
- 标准化和长时间的抗凝治疗对于改善PE癌症患者的治疗结果至关重要.
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